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How does Anticholinesterase work in myasthenia gravis? Class Summary. Anticholinesterase inhibitors interfere with the degradation of acetylcholine (ACh) by AChE, thereby increasing the amount of ACh available at the neuromuscular junction (NMJ) and increasing the chance of activating the acetylcholine receptors (AChRs).
What are the first signs of myasthenia gravis? In more than half the people who develop myasthenia gravis, their first signs and symptoms involve eye problems, such as: Drooping of one or both eyelids (ptosis). Double vision (diplopia), which may be horizontal or vertical, and improves or resolves when one eye is closed.
Does fludrocortisone increase blood pressure? Fludrocortisone mimics the actions of aldosterone which is a steroid that is naturally produced by the body. The physiological effects of fludrocortisone are dose dependent. Small oral doses of fludrocortisone cause an increase in blood pressure, sodium retention, and increases urinary potassium excretion.
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