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How does Anticholinesterase work in myasthenia gravis? Class Summary. Anticholinesterase inhibitors interfere with the degradation of acetylcholine (ACh) by AChE, thereby increasing the amount of ACh available at the neuromuscular junction (NMJ) and increasing the chance of activating the acetylcholine receptors (AChRs).
What are the first signs of myasthenia gravis? In more than half the people who develop myasthenia gravis, their first signs and symptoms involve eye problems, such as: Drooping of one or both eyelids (ptosis). Double vision (diplopia), which may be horizontal or vertical, and improves or resolves when one eye is closed.
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